Dive into every Week 5 NFL clash — expert previews, bold picks, and key insights.
By Muhammad MubashirPublished On 07 Oct 2025
The Week 5 NFL schedule for the 2025 season brings some exciting matchups.
Browns rookie QB Dillon Gabriel is making his NFL debut in London against the Vikings. Old teammates in Carolina, QBs Baker Mayfield and Sam Darnold, will face off again in the Bucs-Seahawks matchup. And Commanders QB Jayden Daniels makes his return from injury against the Chargers.
We have you covered with everything you need to know. Our NFL Nation reporters take you inside the locker room with the best thing they heard this week, and ESPN Research provides a key stat to know and a betting nugget for each contest. Plus, analytics writer Seth Walder makes a bold prediction for each matchup, and fantasy analyst Eric Moody shares fantasy football intel. We also have Football Power Index (FPI) matchup quality ratings (out of 100) and game projections, and three analysts -- Pamela Maldonado, Moody and Walder -- give us final score picks for every game.
Let's get into the full Week 5 slate, which culminates with a "Monday Night Football" matchup between the Chiefs and Jaguars on ESPN. (Game times are Sunday unless otherwise noted.)
